Reaper is a DAW that runs on Mac/PC/Linux - it is also highly customizable and configurable, both via its own preferences and also through scripting which allows for very deep and detailed changes.
It's becoming popular amongst media composers due to this customizable workflow.
Programmer Leon Bradley, together with media composers TJ Lindgren and Stephan Römer as http://LBXTools.com are working on a serious controller script called Smart Knobs2. Which deeply integrates custom controller integration into the Reaper workflow - designed for the Behringer X-Touch natively, but it will also work with many other hardware controllers.
We spoke to them about the project.
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Desktop polyphonic MIDI and CV/Gate
Deep look at the new generation interface
Artist, Producer, Remixer and Performer